(en gras les membres de l'équipe Hajduch)
- Phan, F., Bourron, O., Foufelle, F., Le Stunff, H. & Hajduch, E. Sphingosine-1-phsophate signalling in the heart: exploring emerging perspectives in cardiopathology. FEBS Letters [2024] sous presse
- Phan, F., Bourron, O., Foufelle, F., Le Stunff, H. & Hajduch, E. Sphingosine-1-phsophate signalling in the heart: exploring emerging perspectives in cardiopathology. FEBS Letters [2024] sous presse
- Ali-Berrada, S., Guitton, J., Tan-Chen, S., Gyulkhandanyan, A., Hajduch, E. & Le Stunff, H. Circulating sphingolipids and glucose homeostasis: an update. International Journal of Molecular Sciences [2023] 24 :12720
- Bandet, C.L., Tan-Chen, S., Ali-Berrada, S., Campana, M., Poirier, M., Blachnio-Zabielska,
A., Pais-de-Barros, J.P., Rouch, C., Ferré, P., Foufelle, F., Le Stunff, H.
& Hajduch, E. Ceramide
analogue C2-cer induces a loss in insulin sensitivity in muscle cells through
the salvage/recycling pathway. Journal of Biological Chemistry [2023] 299: 104815
- Hajduch, E. & Le Stunff, H. Serum ceramides could predict durable remission following gastric bypass surgery. Med [2022] 3: 440-441
- Biachnio-Zabielska, A., Hajduch, E. & Le Stunff, H. The role of sphingolipid metabolism in the development of type 2 diabetes and obesity. Frontiers in Endocrinology [2022] (Editorial) 12: 835751
- Bonilha, I., Hajduch, E., Luchiari, B., Nadruz, W., Le
Goff, W. & Sposito, A.C. The reciprocal relationship between LDL metabolism
and type 2 diabetes mellitus. Metabolites
[2021] 11: 807
- Bandet, C.L. & Hajduch, E. CERT-dependent ceramide transport, a crucial process in cells. Journal of Diabetes and Clinical Research [2021] 3: 40-45
- Hajduch, E., Lachkar, F. Ferré, P. & Foufelle, F. Roles of ceramides in non-alcoholic fatty acid liver diseases. Journal of Clinical Medicine [2021] 10: 792
- Carlier, A., Phan, F., Szpiegel, A., Hajduch, E., Salem, J.-E., Gautheron, J., Le Goff, W., Guérin, M., Lachkar, F., Ratziu, V., Hartemann, A., Ferré, P., Foufelle, F. & Bourron, O. Dihydroceramides in triglyceride-enriched VLDL are associated with nonalcoholic fatty liver disease severity in type 2 diabetes. Cell Reports Medicine [2020] 1: 100154
- Tan-Chen, S., Guitton, J., Bourron, O., Le Stunff, H. & Hajduch, E. Sphingolipid metabolism and signaling in skeletal muscle: from physiology to physiopathology. Frontiers Endocrinology [2020] 11: 491
- Guitton, J., Bandet, C.L., Mariko, M.L., Tan-Chen, S., Bourron, O., Benomar, Y., Hajduch, E. & Le Stunff, H. Sphingosine-1-phosphate metabomism in the regulation of obesity/type 2 diabetes. Cells [2020] 9:1682
- Tan-Chen, S., Bourron, O. & Hajduch, E. Céramides, acteurs cruciaux dans le développement de l’insulino-résistance et du diabète de type 2. Médecine / Sciences [2020] 36: 497-503
- Bandet, C.L., Tan-Chen, S., Bourron, O., Le Stunff, H. & Hajduch, E. Sphingolipid metabolism: new insight into ceramide-induced lipotoxicity in muscle cells. International Journal of Molecular Sciences [2019] 20: 479
- Bandet, C.L., Mahfouz, R., Véret, J., Sotiropoulos, A., Poirier, M., Giussani, P., Campana, M., Philippe, E., Blachnio-Zabielska, A., Ballaire, R., Le Liepvre, X., Bourron, O., Berkeš, D., Górski, J., Ferré, P., Le Stunff, H., Foufelle, F. & Hajduch, E. Ceramide Transporter CERT is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes [2018] 67:1258-1271
- Campana, M., Bellini, L., Rouch, C., Rachdi, L., Coant, N., Butin, N., Bandet, C.L., Philippe, E., Meneyrol, K., Kassis, N., Dairou, J., Scharfmann, R., Hajduch, E., Colsch, B., Magnan, C. & Le Stunff, H. Inhibition of central de novo ceramides synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular Metabolism [2018] 8:23-36
- Spigel, A., Venteclef, N., Carlier, A., Hainault, I., Batto, A-F., Hajduch, E., Bernard, C., Ktorza, A., Gautier, J-F., Ferré, P., Bourron, O. & Foufelle, F. Lipid environment induces an endoplasmic reticulum stress, TXNIP expression and inflammation in immune cells of type 2 diabetic patients. Diabetologia [2018] 61:399-412
- Tan-Chen, S., Bourron, O. & Hajduch, E. Céramides, acteurs cruciaux dans le développement de l’insulino-résistance et du diabète de type 2. Médecine / Sciences [2020] 36: 497-503
- Bandet, C.L., Tan-Chen, S., Bourron, O., Le Stunff, H. & Hajduch, E. Sphingolipid metabolism: new insight into ceramide-induced lipotoxicity in muscle cells. International Journal of Molecular Sciences [2019] 20: 479
- Bandet, C.L., Mahfouz, R., Véret, J., Sotiropoulos, A., Poirier, M., Giussani, P., Campana, M., Philippe, E., Blachnio-Zabielska, A., Ballaire, R., Le Liepvre, X., Bourron, O., Berkeš, D., Górski, J., Ferré, P., Le Stunff, H., Foufelle, F. & Hajduch, E. Ceramide Transporter CERT is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes [2018] 67:1258-1271
- Campana, M., Bellini, L., Rouch, C., Rachdi, L., Coant, N., Butin, N., Bandet, C.L., Philippe, E., Meneyrol, K., Kassis, N., Dairou, J., Scharfmann, R., Hajduch, E., Colsch, B., Magnan, C. & Le Stunff, H. Inhibition of central de novo ceramides synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular Metabolism [2018] 8:23-36
- Spigel, A., Venteclef, N., Carlier, A., Hainault, I., Batto, A-F., Hajduch, E., Bernard, C., Ktorza, A., Gautier, J-F., Ferré, P., Bourron, O. & Foufelle, F. Lipid environment induces an endoplasmic reticulum stress, TXNIP expression and inflammation in immune cells of type 2 diabetic patients. Diabetologia [2018] 61:399-412
- Trang Tran, T.T., Graziela Postal, B., Demignot, S., Ribeiro, A., Osinski, C., Pais de Barros, J.-P., Blachnio-Zabielska, A., Leturque, A., Rousset, M., Ferré, P., Hajduch, E.*, Carrière, V.* A short-term palmitate supply impairs intestinal insulin signaling and triglyceride secretion via ceramide production. Journal of Biological Chemistry [2016] 291: 16329-16338 *Contributed equally to the study.
- Hage Hassan, R., Pacheco de Sousa, A.C., Mahfouz, R., Hainault, I., Blachnio-Zabielska, A., Bourron, O., Gorski, J., Ferré, P., Foufelle, F. & Hajduch, E. Sustained action of ceramide on the insulin signaling pathway in muscle cells: Implication of the double-stranded RNA activated protein kinase. Journal of Biological Chemistry [2016] 291:3019-3029.
- Campana, M., Bellini, L., Mahfouz, R., Carlier, A., Magnan, C., Hajduch, E. & Le Stunff, H. Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes. Expert Opinion on Therapeutic Targets [2015] 19: 1037-1050 (Revue)
- Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C, Bourron, O., Ferré, P, Foufelle, f., Hundal, HS & Hajduch, E. Characterising the Inhibitory Actions of Ceramide upon Insulin Signalling in Different Skeletal Muscle Cell Models: a Mechanistic Insight. Plos One [2014] 9(7):e101865
- Hage Hassan, R., Bourron, O. & Hajduch, E. Defect of insulin signal in peripheral tissues: important role of ceramide. World Journal of Diabetes [2014] 5: 244-257 (Revue)
- Nardi, F. Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H.S. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. PloS One [2014] 9:e92255
- Hajduch, E. & Bourron O. Type 2 diabetes: ceramides as a therapeutic target? Clinical Lipidology [2013] 8: 607-609 (Editorial)
- Flamment, M., Hajduch, E., Ferré, P. & Foufelle, F. New insights into ER stress-induced insulin resistance. Trends in Endocrinology and Metabolism [2012] 23: 381-390 (revue)
- Hage Hassan, R., Hainault, I., Samama, C., Lasnier,
F., Ferré, P., Foufelle, F. & Hajduch, E. Endoplasmic reticulum does
not mediate palmitate-induced insulin resistance in muscle cells. Diabetologia
[2012] 55: 204-214
- Turban, S. & Hajduch, E. Protein kinase C
isoforms: mediators of reactive lipid metabolites in the development of insulin
resistance. FEBS Letters [2011] 585: 269-274 (Mini-revue)
- Le Lay, S., Blouin, C.M., Briand, N., Château, D.,
Lasnier, F., Le Liepvre, Hajduch, E. & Dugail, I. The lipoatrophic
caveolin-1 deficient mouse model reveals autophagy in mature adipocytes.
Autophagy [2010] 16: 754-763
- Blouin, C.M., Le Lay, S., Eberl, A., Köfeler, H.C.,
Chiara Guerrera, I., Klein, C., Le Liepvre, X., Lasnier, F., Bourron, O.,
Gautier, J-F., Ferré, P. & Hajduch, E., & Dugail, I. Lipid
droplet analysis in caveolin-deficient adipocytes: alterations in surface
phospholipid composition and maturation defects. Journal of Lipid Research
[2010] 51: 945-956
- Bourron, O., Daval, M., Hainault, I., & Hajduch,
E., Servant, J.M., Gautier, J.F., Ferré, P. & Foufelle, F. Biguanides
and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through
an activation of AMP-activated protein kinase. Diabetologia [2010] 53: 768-778
- Blouin, C.M., Prado, C., Takane, K.K., Lasnier, F.,
Garcia-Ocana, A., Ferré, P., Dugail, I. & Hajduch, E. Plasma
membrane subdomain compartmentalization contributes to distinct mechanisms of
ceramide action on insulin signaling. Diabetes [2010] 59: 600-610
- Stretton, C., Litherland, G.J., Moynihan, A., Hajduch,
E. & Hundal, H.S. Expression and modulation of TUB by insulin and
thyroid hormone in primary rat and murine 3T3-L1 adipocytes. Biochemical and
Biophysical Research Communications [2009] 390: 1328-1333
- Le Lay, S., Blouin, C.M., Hajduch, E. &
Dugail, I. Filling up adipocytes with lipids. Lessons from caveolin-1
deficiency. Biochimica Biophysica Acta [2009] (Revue) 1791: 514-518
- Blouin, C.M., Le Lay, S., Lasnier, F., Dugail, I.
& Hajduch, E. Regulated association of caveolins to lipid droplets
during differentiation of 3T3-L1 adipocytes. Biochemical and Biophysical
Research Communications [2008] 376: 331-335
- Hajduch, E., Turban, S., Le Liepvre, X., Le
Lay, S., Lipina, C, Dimopoulos, K., Dugail, I. & Hundal, H.S. Targeting of
PKB and PKCzeta to caveolin-enriched microdomains represents an crucial step
underpinning the disruption in PKB-directed signaling by ceramide. Biochemical
Journal [2008] 410: 369-379
- Dugail, I. & Hajduch, E. A new look for
adipocyte lipid droplets: towards a role in the sensing of triacylglycerol
stores? Cellular and
Molecular Life Sciences [2007] 64:2452-2458 (Revue)
-
Blouin, C., Hajduch, E. & Dugail, I. Un regard neuf sur les
gouttelettes lipidiques des adipocytes : jouent-elles un rôle dans la détection
de l’état du stock de triglycérides ? Journal de la Société de Biologie [2006]
200 : 77-86
-
Perrier, S., Darakhshan, F. & Hajduch, E. Il-1 receptor antagonist
in metabolic diseases: Dr Jekyll or Mr Hyde? FEBS Letters
[2006] (Mini-revue) 580:6289-6294
- Robichon, C., Varret, M., Le Liepvre, X, Lasnier,
F., Hajduch, E., Ferré, P. & Dugail, I. DnaJA4 is a SREBP-regulated
chaperone involved in the cholesterol biosynthetic pathway. Biochimica
Biophysica Acta [2006] 1761: 1107-1113
- Le Lay, S.*, Hajduch, E.*, Lindsay, M.R., Le
Liepvre, X., Thiele, C., Ferré, P., Parton, R.G., Kurzchalia, T., Simons, K.
& Dugail, I. Cholesterol-induced caveolin targeting to lipid droplets: a
role for caveolar endocytosis. Traffic [2006] 7: 549-561 * Contributed equally
to the study
- Turban, S., Beardmore, V.A., Carr, J.M., Sakamoto,
K., Hajduch, E., Arthur, J.S.C. & Hundal, H.S. Insulin-stimulated
glucose uptake does not require p38 MAP kinase in adipose tissue or skeletal
muscle. Diabetes [2005] 54: 3161-3168
- Tondu, A.L., Robichon, C., Yvan-Charvet, L., Donne,
N., Le Liepvre, X., Hajduch, E., Ferré, P., Dugail, I. & Dagher, G.
Insulin and angiotensin II induces the translocation of scavenger receptor type
B1 from intracellular sites to the plasma membrane of 3T3-L1 adipocytes.
Journal of Biological Chemistry [2005] 280: 33536-33540
- Daval, M., Biot-Dupuy, F., Bazin, R., Viollet, B.,
Vaulont, S., Hajduch, E., Ferré, P. & Foufelle, F. Anti-lipolytic
action of AMP-activated protein kinase in rodent adipocytes. Journal of
Biological Chemistry [2005] 280: 25250-25257
- MacAulay, K., Blair, A.S., Hajduch, E.,
Terashima, T., Baba, O., Sutherland, C. & Hundal, H.S. Constitutive
activation of GSK3beta down regulate glycogen synthase abundance and glycogen
deposition in rat skeletal muscle cells. Journal of Biological Chemistry [2005]
280 : 9509-9518
- Hyde, R., Hajduch, E., Taylor, P.M. &
Hundal, H.S. Ceramide down-regulates System A amino acid transport and protein
synthesis in rat skeletal muscle cells. FASEB Journal [2005] 19 : 461-463
- Powell, D.J., Turban, S., Gray, A., Hajduch, E.
& Hundal, H.S. Intracellular ceramide synthesis and PKCzeta activation play
an essential role in palmitate-induced insulin resistance in rat L6 skeletal
muscle cells. Biochemical Journal [2004] 382: 619-29
- Litherland, G.J., Hajduch, E., Gould, G.W
& Hundal, H.S. Fructose transport and metabolism in adipose tissue of Zucker
rats: diminished GLUT5 activity during obesity and insulin resistance.
Molecular and Cellular Biochemistry [2004] 261: 23-33
- Powell, D.J., Hajduch, E., Kular, G. &
Hundal, H.S. Ceramide disables 3-phosphoinositide binding to the plekstrin
homology domain of PKB/Akt by a PKCzeta-dependent mechanism. Molecular and
Cellular Biology [2003] 23: 7794-7808
- MacAulay, K., Hajduch, E., Blair, A.S.,
Coghlan, M.P., Smith, S. & Hundal, H.S. Use of Lithium and SB-415286 to
explore the role of glycogen synthase kinase-3 in the regulation of glucose
transport and glycogen synthase. European Journal of Biochemistry [2003] 270:
3829-3838
- Hajduch, E., Litherland, G.J., Brot-Laroche,
E. & Hundal, H.S. Insulin regulates the expression of the GLUT5 transporter
in L6 skeletal muscle cells. FEBS Letters [2003] 549: 77-82
- Christie, G.R., Hajduch, E., Hundal, H.S.,
Proud, C.,G. & Taylor, P.M. Intracellular sensing of amino acids in Xenopus
laevis oocytes stimulates p70S6 kinase in a TOR-dependent manner. Journal of
Biological Chemistry [2002] 277:9952-9957
- Hyde, R, Christie, G.R., Litherland, G.J., Hajduch,
E., Taylor, P.M. & Hundal, H.S. Subcellular localisation and adaptive
up-regulation of the System A (SAT2) amino acid transporter in skeletal muscle
cells and adipocytes. Biochemical Journal [2001] 355: 563-568 (research
communication)
- Hajduch, E., Balendran, A., Batty, I.H.,
Litherland, G.J., Blair, A.S., Downes, C.P. & Hundal, H.S. Ceramide impairs
the insulin-dependant membrane recruitment of protein kinase B leading to a
loss in downstream signalling in L6 skeletal muscle cells. Diabetologia [2001]
44: 173-183
- Litherland, G.J., Hajduch, E. & Hundal,
H.S. Intracellular signalling mechanisms regulating glucose transport in
insulin-sensitive tissues. Molecular Membrane Biology [2001] 18: 195-204
(Revue)
- Hajduch, E., Litherland, G.J. & Hundal,
H.S. Glucose homeostasis – A key role for Protein Kinase B? FEBS Letters [2001]
492: 199-203 (Mini-revue)
- Peyrollier, K., Hajduch, E., Gray, A.,
Litherland, G.J., Prescott, A.R., Leslie, N.R. & Hundal, H.S. A role for
the actin cytoskeleton in the hormonal and growth-factor mediated activation of
protein kinase B. Biochemical Journal [2000] 352: 617-622 (research
communication)
- Fryer, L.G.D., Hajduch, E., Rencurel, F.,
Salb, I.P., Hundal, H.S., Hardie, G.D. & Carling, D. Activation of glucose
transport by AMP-activated protein kinase via stimulation of nitric oxide
synthase. Diabetes [2000] 49: 1978-1985
- Peyrollier, K., Hajduch, E., Blair, A.S.,
Hyde, R. & Hundal, H.S. Leucine induces a transient activation of
PI3-kinase and p70 S6 kinase: Associated inactivation of GSK3 and upregulation
of system A amino acid transport in L6 muscle cells. Biochemical Journal [2000]
350: 361-368
- Hajduch, E., Heyes, R.R., Watt, P.W. &
Hundal, H.S. Lactate transport in rat adipocytes: Identification of
monocarboxylate transporter 1 (MCT1) and its modulation during
streptozotocin-induced diabetes. FEBS Letters [2000] 479: 89-92
- Blair, A.S., Hajduch, E., Litherland, G.J.
& Hundal, H.S. Regulation of glucose transport and glycogen synthesis in L6
muscle cells during oxidative stress: evidence for cross-talk between the
insulin and SAPK2/p38 mitogen-activated protein kinase signalling pathways.
Journal of Biological Chemistry [1999] 274: 36293-36299
- Hajduch, E., Rencurel, F., Balendran, A.,
Batty, I.H., Downes, C.P. & Hundal, H.S. Serotonin (5-HT), a novel
regulator of glucose transport in rat skeletal muscle. Journal of Biological Chemistry
[1999] 274: 13563-13568
- Hajduch, E., Dombrowski, L., Darakhshan, F.,
Rencurel, F., Marette, A. & Hundal, H.S. Biochemical localisation of the
5-HT (serotonin) receptor in rat skeletal muscle. Biochemical and Biophysical
Research Communications [1999] 357: 359-372
- Darakhshan, F., Hajduch, E., Kristiansen, S.,
Richter, E. & Hundal, H.S. Biochemical and functional characterisation of
the GLUT5 fructose transporter in rat skeletal muscle. Biochemical Journal
[1998] 336: 361-366
- Hajduch, E., Alessi, D.R., Hemmings, B.A.
& Hundal, H.S. Constitutive activation of protein kinase B alpha by
membrane targeting promotes glucose and system A amino acid transport, protein
synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.
Diabetes [1998] 47: 1006-1013
- Hajduch, E., Darakhshan, F. & Hundal,
H.S. Fructose uptake in rat adipocytes: GLUT5 expression, substrate regulation
and effects of streptozotocin-induced diabetes. Diabetologia [1998] 41: 821-828
- McDowell, H.E., Walker, T., Hajduch, E.,
Christie, G.R., Batty, I.H., Downes, C.P. & Hundal, H.S. Phophoinositide
3-kinase (PI3K) is activated by cellular stress but is not required for the
stress-induced activation of glucose transport in L6 rat skeletal muscle cells.
European Journal of Biochemistry [1997] 247: 306-313
- Hajduch, E., Aledo, J.C., Watts, C. & Hundal,
H.S. Proteolytic cleavage of cellubrevin and vesicle-associated membrane
protein (VAMP) by tetanus toxin does not impair insulin-stimulated glucose
transport or GLUT4 translocation in rat adipocytes. Biochemical Journal [1997]
321: 233-238
- Aledo, J.C., Hajduch, E., Darakhshan, F.
& Hundal, H.S. Analyses of the co-localisation of cellubrevin and the GLUT4
glucose transporter in rat and human insulin-responsive tissues. FEBS Letters
[1996] 395: 211-216
- Nivet, V., Hajduch, E., Hainault, I.,
Delattre, J., Lavau, M. & Hainque, B. Sensitive northern blot hybridisation
using digoxigenin RNA probes for the mRNA detection of two glucose transporter
isoforms. Cellular and Molecular Biology [1995] 41: 979-984
- Hajduch, E., Hainault, I., Meunier, C.,
Jardel, C., Hainque, B., Guerre-Millo, M. & Lavau, M. Regulation of glucose
transporters in cultured rat adipocytes: synergistic effect of insulin and
dexamethasone on GLUT4 gene expression through promoter activation.
Endocrinology [1995] 136: 4782-4789
- Hainault, I., Hajduch, E. & Lavau, M. Fatty
genotype-induced increase in GLUT4 promoter activity in transfected adipocytes:
delineation of two fa-responsive regions and glucose effect. Biochemical and Biophysical Research
Communications [1995] 209: 1053-1061
- Benhizia, F., Hainault, I., Segourne, C., Lagrange,
D., Hajduch, E., Guichard, C., Malewiak, M.I., Quignard-Boulangé, A.,
Lavau, M. & Griglio, S. Effects of a fish oil lard diet on rat plasma
lipoproteins, liver fatty acid synthase, and lipolytic enzymes. American
Journal of Physiology [1994] 267: E975-E982
- Hainault, I., Carlotti, M., Hajduch, E.,
Guichard, C. & Lavau, M Fish oil in a high lard diet prevents obesity,
hyperlipemia, and adipocyte insulin-resistance in rats. Annals of the New York
Academy of Sciences [1993] 683: 98-101
- Carlotti, M., Hainault, I., Guichard, C., Hajduch,
E. & Lavau, M. Beneficial effects of a fish oil enriched high lard diet
on obesity and hyperlipemia in Zucker rats. Annals of the New York Academy of
Sciences [1993] 683: 349-350
- Hajduch, E., Guerre-Millo, M., Hainault, I.,
Guichard, C. & Lavau, M. Expression of glucose transporters (GLUT1 and
GLUT4) in primary cultured rat adipocytes: differential evolution with time and
chronic insulin effect. Journal
of Cellular Biochemistry [1992] 49: 251-258
