Publications des thésards

Sarah Ali (2022- ) 

- Ali-Berrada, S., Guitton, J., Tan-Chen, S., Gyulkhandanyan, A., Hajduch, E., Le Stunff, H. Circulating sphingolipids and glucose homeostasis: an update. International Journal of Molecular Sciences [2023] 24 :12720 

- Bandet, C.L., Tan-Chen, S., Ali-Berrada, S., Campana, M., Poirier, M., Blachnio-Zabielska, A., Pais-de-Barros, J.P., Rouch, C., Ferré, P., Foufelle, F., Le Stunff, H. and Hajduch, E. Ceramide analogue C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway. Journal of Biological Chemistry [2023] 299:104815

 

 Sophie Tan-Chen (2021- )

- Ali-Berrada, S., Guitton, J., Tan-Chen, S., Gyulkhandanyan, A., Hajduch, E., Le Stunff, H. Circulating sphingolipids and glucose homeostasis: an update. International Journal of Molecular Sciences [2023] 24 :12720 

- Bandet, C.L., Tan-Chen, S., Ali-Berrada, S., Campana, M., Poirier, M., Blachnio-Zabielska, A., Pais-de-Barros, J.P., Rouch, C., Ferré, P., Foufelle, F., Le Stunff, H. and Hajduch, E. Ceramide analogue C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway. Journal of Biological Chemistry [2023] 299: 104815

Tan-Chen, S., Guitton, J., Bourron, O., Le Stunff, H. & Hajduch, E. Sphingolipid Metabolism and Signaling in Skeletal Muscle: from physiology to physiopathology. Frontiers Endocrinology [2020] 8: 491

Guitton, J., Bandet, C.L., Mariko, M.L., Tan-Chen, S., Bourron, O., Benomar, Y., Hajduch, E. & Le Stunff, E. Sphingosine-1-phosphate metabolism in the regulation of obesity/type 2 diabetes. Cells [2020] 9:1682

Tan-Chen, S., Bourron, O. & Hajduch, E. Céramides, acteurs cruciaux dans le développement de l’insulino-résistance et du diabète de type 2. médecine / sciences [2020] 36 : 497-503

Cécile Bandet (2014-2018) 

- Bandet, C.L., Tan-Chen, S., Ali-Berrada, S., Campana, M., Poirier, M., Blachnio-Zabielska, A., Pais-de-Barros, J.P., Rouch, C., Ferré, P., Foufelle, F., Le Stunff, H. and Hajduch, E. Ceramide analogue C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway. Journal of Biological Chemistry [2023] 299: 104815

Bandet, CL. & Hajduch, E. CERT-dependent ceramide transport, a crucial process in cells. Journal of Diabetes and Clinical Research [2021] 3: 40-45

Guitton, J., Bandet, C.L., Mariko, M.L., Tan-Chen, S., Bourron, O., Benomar, Y., Hajduch, E. & Le Stunff, E. Sphingosine-1-phosphate metabolism in the regulation of obesity/type 2 diabetes. Cells [2020] 9:1682

Bandet, C.L., Tan-Chen, S., Bourron, O., Le Stunff, H. & Hajduch, E. Sphingolipid metabolism: new insight into ceramide-induced lipotoxicity in muscle cells. International Journal of Molecular Sciences [2019] 20: 479

Bandet, C.L., Mahfouz, R., Véret, J., Sotiropoulos, A., Poirier, M., Giussani, P., Campana, M., Philippe, E., Blachnio-Zabielska, A., Ballaire, R., Le Liepvre, X., Bourron, O., Berkeš, D., Górski, J., Ferré, P., Le Stunff, H., Foufelle, F. & Hajduch, E. The Ceramide Transporter CERT is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes [2018] 67: 1258-1271

Campana, M., Bellini, L., Rouch, C., Rachdi, L., Coant, N., Butin, N., Bandet, C.L., Philippe, E., Meneyrol, K., Kassis, N., Dairou, J., Scharfmann, R., Hajduch, E., Colsch, B., Magnan, C. & Le Stunff, H. Inhibition of central de novo ceramides synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Molecular Metabolism [2018] 8:23-36

Rana Mahfouz (2011-2014)

Bandet, C.L., Mahfouz, R., Véret, J., Sotiropoulos, A., Poirier, M., Giussani, P., Campana, M., Philippe, E., Blachnio-Zabielska, A., Ballaire, R., Le Liepvre, X., Bourron, O., Berkeš, D., Górski, J., Ferré, P., Le Stunff, H., Foufelle, F. & Hajduch, E. The Ceramide Transporter CERT is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes [2018] 67: 1258-1271

Hage Hassan, R., Pacheco de Sousa, A.C., Mahfouz, R., Hainault, I., Blachnio-Zabielska, A., Bourron, O., Gorski, J., Ferré, P., Foufelle, F. & Hajduch, E. Sustained action of ceramide on the insulin signaling pathway in muscle cells: Implication of the double-stranded RNA activated protein kinase. Journal of Biochemical Chemistry [2016] 291:3019-3029

Campana, M., Bellini, L., Mahfouz, R., Carlier, A., Magnan, C., Hajduch, E. & Le Stunff, H. Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes. Expert Opinion on Therapeutic Targets [2015] 19: 1037-1050

Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C, Bourron, O., Ferré, P, Foufelle, f., Hundal, HS & Hajduch, E. Characterising the Inhibitory Actions of Ceramide upon Insulin Signalling in Different Skeletal Muscle Cell Models: a Mechanistic Insight. Plos One [2014] 9(7): e101865

Rima Hage Hassan (2010-2013)

Hage Hassan, R., Pacheco de Sousa, A.C., Mahfouz, R., Hainault, I., Blachnio-Zabielska, A., Bourron, O., Gorski, J., Ferré, P., Foufelle, F. & Hajduch, E. Sustained action of ceramide on the insulin signaling pathway in muscle cells: Implication of the double-stranded RNA activated protein kinase. Journal of Biochemical Chemistry [2016] 291:3019-3029.

Hage Hassan, R., Bourron, O. & Hajduch, E. Defect of insulin signal in peripheral tissues: important role of ceramide. World Journal of Diabetes [2014] 5: 244-257

Nardi, F. Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. & Hundal, H.S. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells  involves counter modulation of PP2A. PloS One [2014] 9:e92255

Hage Hassan, R., Hainault, I., Samama, C., Lasnier, F., Ferré, P., Foufelle, F. & Hajduch, E. Endoplasmic reticulum does not mediate palmitate-induced insulin resistance in muscle cells. Diabetologia [2012] 55: 204-214

Cédric Blouin (2003-2008)

Le Lay, S., Blouin, C.M., Briand, N., Château, D., Lasnier, F., Le Liepvre, Hajduch, E. & Dugail, I. The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes. Autophagy [2010] 16: 754-763

Blouin, C.M., Le Lay, S., Eberl, A., Köfeler, H.C., Chiara Guerrera, I., Klein, C., Le Liepvre, X., Lasnier, F., Bourron, O., Gautier, J-F., Ferré, P. & Hajduch, E., & Dugail, I. Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects. Journal of Lipid Research [2010] 51: 945-956

Blouin, C.M., Prado, C., Takane, K.K., Lasnier, F., Garcia-Ocana, A., Ferré, P., Dugail, I. & Hajduch, E. Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling. Diabetes [2010] 59: 600-610

Le Lay, S., Blouin, C.M., Hajduch, E. & Dugail, I. Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency. Biochimica Biophysica Acta [2009] (Revue) 1791: 514-518

Blouin, C.M., Le Lay, S., Lasnier, F., Dugail, I. & Hajduch, E. Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications [2008] 376: 331-335

Blouin, C., Hajduch, E. & Dugail, I. Un regard neuf sur les gouttelettes lipidiques des adipocytes : jouent-elles un rôle dans la détection de l’état du stock de triglycérides ? Journal de la Société de Biologie [2006] 200 : 77-86

 

Darren Powell (2001-2004)

Powell, D.J., Hajduch, E., Kular, G. & Hundal, H.S. Ceramide disables 3-phosphoinositide binding to the plekstrin homology domain of PKB/Akt by a PKCzeta-dependent mechanism. Molecular and Cellular Biology [2003] 23: 7794-7808

Powell, D.J., Turban, S., Gray, A., Hajduch, E. & Hundal, H.S. Intracellular ceramide synthesis and PKCzeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochemical Journal [2004] 382: 619-29

Hundal, H.S., Hyde, R., Powell, D.J., Hajduch, E., Dimopoulos, N., Turban, S. & Taylor, P.M. Ceramide is a negative regulator of insulin action, nutrient uptake and protein synthesis in cultured skeletal muscle cells. Book chapter in Hepatic Encephalopathy and Nitrogen Metabolism (Eds Haussinger, Kiircheis, Schliess) [2006] 373-386

 

Anna Blair (1998-2002)

Blair, A.S., Hajduch, E., Litherland, G.J. & Hundal, H.S. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress: evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signalling pathways. Journal of Biological Chemistry [1999] 274: 36293-36299

Peyrollier, K., Hajduch, E., Blair, A.S., Hyde, R. & Hundal, H.S. Leucine induces a transient activation of PI3-kinase and p70 S6 kinase: Associated inactivation of GSK3 and upregulation of system A amino acid transport in L6 muscle cells. Biochemical Journal [2000] 350: 361-368

Hajduch, E., Balendran, A., Batty, I.H., Litherland, G.J., Blair, A.S., Downes, C.P. & Hundal, H.S. Ceramide impairs the insulin-dependant membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia [2001] 44: 173-183

MacAulay, K., Hajduch, E., Blair, A.S., Coghlan, M.P., Smith, S. & Hundal, H.S. Use of Lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. European Journal of Biochemistry [2003] 270: 3829-3838

MacAulay, K., Blair, A.S., Hajduch, E., Terashima, T., Baba, O., Sutherland, C. & Hundal, H.S. Constitutive activation of GSK3 down regulate glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. Journal of Biological Chemistry [2005] 280 : 9509-9518